Professor Angela Lange

Angela B. Lange

Professor


Campus

UTM

CSB Appointment

Full

Research Areas

Animal Biology, Molecular Biology, Neurobiology, Physiology

Education

Ph.D. York 1984

Primary Undergraduate Department

Biology, UTM

Graduate Programs

Cell & Systems Biology

Academic or Administrative Appointments

Vice Dean Faculty, UTM (October 2016 – Present)
Acting Dean, UTM (July 1, 2018 – Dec. 31, 2018)

Research Description

I am an insect physiologist who studies how the nervous system and visceral tissues communicate and integrate information allowing for coordinated behaviours such as egg-laying, digestion, and circulatory function.


Contact Information

Office Phone: 905-828-3971
Office: DV3200G
Lab: DV3017A
Lab Phone: 905-569-4752
Email

Mailing Address

Department of Biology
University of Toronto
3359 Mississauga Road
Mississauga, ON L5L 1C6
Canada

Visit lab’s website


Publications

2018

Jack bean urease modulates neurotransmitter release at insect neuromuscular junctions.

Carrazoni T, Nguyen C, Maciel LF, Delgado-Cañedo A, Stewart BA, Lange AB, Dal Belo CA, Carlini CR, Orchard I
2018, Pesticide biochemistry and physiology, 146, 63-70, 29626993

A Rhodnius prolixus Insulin Receptor and Its Conserved Intracellular Signaling Pathway and Regulation of Metabolism

Defferrari MS, Da Silva SR, Orchard I, Lange AB
2018, Frontiers in Endocrinology, 10.3389/fendo.2018.00745

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2017

Expression and functional characterization of tachykinin-related peptides in the blood-feeding bug, Rhodnius prolixus.

Haddad ANS, Defferrari MS, Hana S, Szeto SG, Lange AB
2018, Peptides, 99, 247-254, 29133203

Cloning and Functional Characterization of Octβ2-Receptor and Tyr1-Receptor in the Chagas Disease Vector, .

Hana S, Lange AB
2017, Frontiers in physiology, 8, 744, 29018364

The involvement of Rhopr-CRF/DH in feeding and reproduction in the blood-gorging insect Rhodnius prolixus.

Mollayeva S, Orchard I, Lange AB
2018, General and comparative endocrinology, 258, 79-90, 28694056

Octopamine and tyramine regulate the activity of reproductive visceral muscles in the adult female blood-feeding bug, .

Hana S, Lange AB
2017, The Journal of experimental biology, 220, 1830-1836, 28235907

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2016

Cloning, localization, and physiological effects of sulfakinin in the kissing bug, Rhodnius prolixus.

Al-Alkawi H, Lange AB, Orchard I
2017, Peptides, 98, 15-22, 28024903

Cloning, localization, and physiological effects of sulfakinin in the kissing bug, Rhodnius prolixus.

Al-Alkawi H, Lange AB, Orchard I
2017, Peptides, 98, 15-22, 28024903

An Insulin-Like Growth Factor in Is Involved in Post-feeding Nutrient Balance and Growth.

Defferrari MS, Orchard I, Lange AB
2016, Frontiers in neuroscience, 10, 566, 28018164

Identification and Characterization of the Corazonin Receptor and Possible Physiological Roles of the Corazonin-Signaling Pathway in Rhodnius prolixus.

Hamoudi Z, Lange AB, Orchard I
2016, Frontiers in neuroscience, 10, 357, 27536213

Isolation and characterization of the corticotropin-releasing factor-related diuretic hormone receptor in Rhodnius prolixus.

Lee HR, Zandawala M, Lange AB, Orchard I
2016, Cellular signalling, 28, 1152-62, 27237375

Cloning and expression of long neuropeptide F and the role of FMRFamide-like peptides in regulating egg production in the Chagas vector, Rhodnius prolixus.

Sedra L, Lange AB
2016, Peptides, 82, 1-11, 27189503

Biostable insect kinin analogs reduce blood meal and disrupt ecdysis in the blood-gorging Chagas’ disease vector, Rhodnius prolixus.

Lange AB, Nachman RJ, Kaczmarek K, Zabrocki J
2016, Peptides, 80, 108-113, 26807486

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2015

Identification of the first insulin-like peptide in the disease vector Rhodnius prolixus: Involvement in metabolic homeostasis of lipids and carbohydrates.

Defferrari MS, Orchard I, Lange AB
2016, Insect biochemistry and molecular biology, 70, 148-59, 26742603

Genome of Rhodnius prolixus, an insect vector of Chagas disease, reveals unique adaptations to hematophagy and parasite infection.

Mesquita RD, Vionette-Amaral RJ, Lowenberger C, Rivera-Pomar R, Monteiro FA, Minx P, Spieth J, Carvalho AB, Panzera F, Lawson D, Torres AQ, Ribeiro JM, Sorgine MH, Waterhouse RM, Montague MJ, Abad-Franch F, Alves-Bezerra M, Amaral LR, Araujo HM, Araujo RN, Aravind L, Atella GC, Azambuja P, Berni M, Bittencourt-Cunha PR, Braz GR, Calderón-Fernández G, Carareto CM, Christensen MB, Costa IR, Costa SG, Dansa M, Daumas-Filho CR, De-Paula IF, Dias FA, Dimopoulos G, Emrich SJ, Esponda-Behrens N, Fampa P, Fernandez-Medina RD, da Fonseca RN, Fontenele M, Fronick C, Fulton LA, Gandara AC, Garcia ES, Genta FA, Giraldo-Calderón GI, Gomes B, Gondim KC, Granzotto A, Guarneri AA, Guigó R, Harry M, Hughes DS, Jablonka W, Jacquin-Joly E, Juárez MP, Koerich LB, Lange AB, Latorre-Estivalis JM, Lavore A, Lawrence GG, Lazoski C, Lazzari CR, Lopes RR, Lorenzo MG, Lugon MD, Majerowicz D, Marcet PL, Mariotti M, Masuda H, Megy K, Melo AC, Missirlis F, Mota T, Noriega FG, Nouzova M, Nunes RD, Oliveira RL, Oliveira-Silveira G, Ons S, Orchard I, Pagola L, Paiva-Silva GO, Pascual A, Pavan MG, Pedrini N, Peixoto AA, Pereira MH, Pike A, Polycarpo C, Prosdocimi F, Ribeiro-Rodrigues R, Robertson HM, Salerno AP, Salmon D, Santesmasses D, Schama R, Seabra-Junior ES, Silva-Cardoso L, Silva-Neto MA, Souza-Gomes M, Sterkel M, Taracena ML, Tojo M, Tu ZJ, Tubio JM, Ursic-Bedoya R, Venancio TM, Walter-Nuno AB, Wilson D, Warren WC, Wilson RK, Huebner E, Dotson EM, Oliveira PL
2015, Proceedings of the National Academy of Sciences of the United States of America, 112, 14936-41, 26627243

Identification, functional characterization, and pharmacological profile of a serotonin type-2b receptor in the medically important insect, Rhodnius prolixus.

Paluzzi JP, Bhatt G, Wang CH, Zandawala M, Lange AB, Orchard I
2015, Frontiers in neuroscience, 9, 175, 26041983

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2014

K+ absorption by locust gut and inhibition of ileal K+ and water transport by FGLamide allatostatins

Robertson L, Donini A, Lange AB
2014, The Journal of experimental biology, 25013112

Adipokinetic hormone signalling system in the Chagas disease vector, Rhodnius prolixus

Zandawala M, Hamoudi Z, Lange AB, Orchard I
2015, Insect molecular biology, 24, 264-76, 25545120

Myoinhibitors controlling oviduct contraction within the female blood-gorging insect, Rhodnius prolixus

Sedra L, Haddad AS, Lange AB
2015, General and comparative endocrinology, 211, 62-8, 25482544

Identification, characterization and expression of a receptor for the unusual myosuppressin in the blood-feeding bug, Rhodnius prolixus

Lee D, James TE, Lange AB
2015, Insect molecular biology, 24, 129-37, 25318350

Functional characterization and expression analysis of the myoinhibiting peptide receptor in the Chagas disease vector, Rhodnius prolixus

Paluzzi JP, Haddad AS, Sedra L, Orchard I, Lange AB
2015, Molecular and cellular endocrinology, 399, 143-53, 25218475

Octopamine modulates a central pattern generator associated with egg-laying in the locust, Locusta migratoria

Wong R, Lange AB
2014, Journal of insect physiology, 63, 1-8, 24530620

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2013

Evidence for a conserved CCAP-signaling pathway controlling ecdysis in a hemimetabolous insect, Rhodnius prolixus

Lee D, Orchard I, Lange AB
2013, Frontiers in neuroscience, 7, 207, 24204330

The distribution and physiological effects of three evolutionarily and sequence-related neuropeptides in Rhodnius prolixus: Adipokinetic hormone, corazonin and adipokinetic hormone/corazonin-related peptide

Patel H, Orchard I, Veenstra JA, Lange AB
2014, General and comparative endocrinology, 195, 1-8, 24184870

Identification and expression of the CCAP receptor in the Chagas’ disease vector, Rhodnius prolixus, and its involvement in cardiac control

Lee D, Vanden Broeck J, Lange AB
2013, PloS one, 8, e68897, 23874803

The female reproductive system of the kissing bug, Rhodnius prolixus: arrangements of muscles, distribution and myoactivity of two endogenous FMRFamide-like peptides

Sedra L, Lange AB
2014, Peptides, 53, 140-7, 23598080

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2012

The distribution and physiological effects of the myoinhibiting peptides in the kissing bug, rhodnius prolixus

Lange AB, Alim U, Vandersmissen HP, Mizoguchi A, Vanden Broeck J, Orchard I
2012, Frontiers in neuroscience, 6, 98, 22783161

An unusual myosuppressin from the blood-feeding bug Rhodnius prolixus

Lee D, Taufique H, da Silva R, Lange AB
2012, The Journal of experimental biology, 215, 2088-95, 22623197

The neural and peptidergic control of gut contraction in Locusta migratoria: the effect of an FGLa/AST

Robertson L, Rodriguez EP, Lange AB
2012, The Journal of experimental biology, 215, 3394-402, 22693021

The regulation of cardiac activity by nitric oxide (NO) in the Vietnamese stick insect, Baculum extradentatum

da Silva R, da Silva SR, Lange AB
2012, Cellular signalling, 24, 1344-50, 22306270

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2011

The Proctolin Gene and Biological Effects of Proctolin in the Blood-Feeding Bug, Rhodnius prolixus

Orchard I, Lee do H, da Silva R, Lange AB
2011, Frontiers in endocrinology, 2, 59, 22654816

Crustacean cardioactive peptide in the Chagas’ disease vector, Rhodnius prolixus: presence, distribution and physiological effects

Lee do H, Lange AB
2011, General and comparative endocrinology, 174, 36-43, 21875591

Sequencing and biological effects of an adipokinetic/hypertrehalosemic peptide in the stick insect, Baculum extradentatum

Malik A, Gäde G, Lange AB
2012, Peptides, 34, 51-6, 21864604

Evidence of a central pattern generator regulating spermathecal muscle activity in Locusta migratoria and its coordination with oviposition

da Silva R, Lange AB
2011, The Journal of experimental biology, 214, 757-63, 21307061

Effects of crustacean cardioactive peptide on the hearts of two Orthopteran insects, and the demonstration of a Frank-Starling-like effect

da Silva SR, da Silva R, Lange AB
2011, General and comparative endocrinology, 171, 218-24, 21295573

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2010

Neuropeptide action in insects and crustaceans

Mykles DL, Adams ME, Gäde G, Lange AB, Marco HG, Orchard I
2010, Physiological and biochemical zoology : PBZ, 83, 836-46, 20550437

Effects of the mycotoxin destruxin A on Locusta migratoria visceral muscles

Ruiz-Sanchez E, Lange AB, Orchard I
2010, Toxicon : official journal of the International Society on Toxinology, 56, 1043-51, 20670642

Neural substrate and allatostatin-like innervation of the gut of Locusta migratoria

Robertson L, Lange AB
2010, Journal of insect physiology, 56, 893-901, 20452355

Rhythmic behaviour and pattern-generating circuits in the locust: key concepts and recent updates

Ayali A, Lange AB
2010, Journal of insect physiology, 56, 834-43, 20303972

Effects of the cyclopeptide mycotoxin destruxin A on the Malpighian tubules of Rhodnius prolixus (Stål)

Ruiz-Sanchez E, Orchard I, Lange AB
2010, Toxicon : official journal of the International Society on Toxinology, 55, 1162-70, 20060849

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2009

Neuropeptides modulate the heart of the stick insect Baculum extradentatum

Lange AB, Calvin A, da Silva R
2009, Annals of the New York Academy of Sciences, 1163, 448-50, 19456383

Neural mechanisms coordinating the female reproductive system in the locust

Lange AB
2009, Frontiers in bioscience (Landmark edition), 14, 4401-15, 19273358

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2008

Tyramine as a possible neurotransmitter/neuromodulator at the spermatheca of the African migratory locust, Locusta migratoria

da Silva R, Lange AB
2008, Journal of insect physiology, 54, 1306-13, 18675822

Tyramine: from octopamine precursor to neuroactive chemical in insects

Lange AB
2009, General and comparative endocrinology, 162, 18-26, 18588893

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2007

Peptidergic control of the heart of the stick insect, Baculum extradentatum

Ejaz A, Lange AB
2008, Peptides, 29, 214-25, 18234395

Dopaminergic control of foregut contractions in Locusta migratoria

Lange AB, Chan K
2008, Journal of insect physiology, 54, 222-30, 17953973

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2006

Neural and hormonal control of muscular activity of the spermatheca in the locust, Locusta migratoria

Lange AB, da Silva R
2007, Peptides, 28, 174-84, 17140702

The association of crustacean cardioactive peptide with the spermatheca of the African migratory locust, Locusta migratoria

da Silva R, Lange AB
2006, Journal of insect physiology, 52, 399-409, 16516227

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2005

Proctolin-like immunoreactivity in the central and peripheral nervous systems of the locust, Locusta migratoria

Clark L, Agricola HJ, Lange AB
2006, Peptides, 27, 549-58, 16309787

Proctolin: A possible releasing factor in the corpus cardiacum/corpus allatum of the locust

Clark L, Zhang JR, Tobe S, Lange AB
2006, Peptides, 27, 559-66, 16309785

The presence and distribution of crustacean cardioactive peptide in the central and peripheral nervous system of the stick insect, Baculum extradentatum

Lange AB, Patel K
2005, Regulatory peptides, 129, 191-201, 15927716

Isolation, cloning, and tissue expression of a putative octopamine/tyramine receptor from locust visceral muscle tissues

Molaei G, Paluzzi JP, Bendena WG, Lange AB
2005, Archives of insect biochemistry and physiology, 59, 132-49, 15986383

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2004

A neurohormonal role for serotonin in the control of locust oviducts

Lange AB
2004, Archives of insect biochemistry and physiology, 56, 179-90, 15274179

Evidence for a possible neurotransmitter/neuromodulator role of tyramine on the locust oviducts

Donini A, Lange AB
2004, Journal of insect physiology, 50, 351-61, 15081828

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2003

The association of serotonin with the alimentary canal of the African migratory locust, Locusta migratoria: distribution, physiology and pharmacological profile

Molaei G, Lange AB
2003, Journal of insect physiology, 49, 1073-82, 14568585

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2002

A review of the involvement of proctolin as a cotransmitter and local neurohormone in the oviduct of the locust, Locusta migratoria

Lange AB
2002, Peptides, 23, 2063-70, 12431745

Evidence for crustacean cardioactive peptide-like innervation of the gut in Locusta migratoria

Donini A, Ngo C, Lange AB
2002, Peptides, 23, 1915-23, 12431729

The effects of crustacean cardioactive peptide on locust oviducts are calcium-dependent

Donini A, Lange AB
2002, Peptides, 23, 683-91, 11897387

Evidence for the association of FMRFamide-related peptides with the spermatheca of Locusta migratoria

Clark J, Lange AB
2002, Peptides, 23, 613-9, 11897379

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