Professor Arneet Saltzman

Arneet Saltzman

Assistant Professor


St. George (downtown)

CSB Appointment


Research Areas

Animal Biology, Bioinformatics / Computational Biology, Cell Biology, Developmental Biology, Genetics / Genomics, Molecular Biology


Research Fellow, Harvard Medical School, 2011-2017
Ph.D. University of Toronto, 2011
B.Sc. (Hons.) Queen’s University, 2003

Primary Undergraduate Department

Cell & Systems Biology

Graduate Programs

Cell & Systems Biology

Research Description

Most of the cells in an organism share the same genome sequence, yet they are able to carry out many distinct functions. Along with other layers of gene regulation, chromatin modification plays a key role in this cellular specialization. Our research focuses on histone modifications such as lysine methylation, and the proteins that recognize these modifications, which are often referred to as chromatin ‘readers’. Chromatin readers can recruit and act as part of diverse chromatin modifying protein complexes to mediate the silencing of many genes with important functions in cell proliferation and differentiation. We will use a combination of genetic, biochemical and genome-wide sequencing approaches to investigate the striking regulatory complexity of chromatin readers. Our research will contribute to a better understanding of how cells acquire and maintain different fates during development, how chromatin readers contribute to epigenetic inheritance, and how aberrant regulation of histone methylation contributes to the pathogenesis of several human diseases, including cancers.

Contact Information

Office Phone: 416-978-5328
Office: RW 514A
Lab: RW 509
Lab Phone: 416-978-4153

Mailing Address

Department of Cell & Systems Biology
University of Toronto
25 Harbord St.
Toronto, ON M5S 3G5

Visit lab’s website

Recent News

Life sciences students honour CSB Teaching Assistants with Teaching Excellence Award

Congratulations to this year’s TA Teaching Excellence Award winners, Ruby He, Mary-Elizabeth Raymond, Andrea-Aditi Taylor and Kathryn McTavish!…

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Pathogenic bacteria modulate pheromone response to promote mating

Wu T, Ge M, Wu M, Duan F, Liang J, Chen M, Gracida X, Liu H, Yang W, Dar AR, Li C, Butcher RA, Saltzman AL, Zhang Y
2023, Nature, 10.1038/s41586-022-05561-9

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Assessing the Binding Specificity of Histone Modification Reader Proteins Using Histone Peptide Arrays.

Soo MW, Saltzman AL
2021, Bio-protocol, 11, e4168, 34692917

Mechanisms of epigenetic regulation by C. elegans nuclear RNA interference pathways

Seroussi U, Li C, Sundby AE, Lee TL, Claycomb JM, Saltzman AL
2021, Seminars in Cell & Developmental Biology, 10.1016/j.semcdb.2021.11.018

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Emerging Roles for Chromo Domain Proteins in Genome Organization and Cell Fate in C. elegans

DasGupta A, Lee TL, Li C, Saltzman AL
2020, Frontiers in Cell and Developmental Biology, 10.3389/fcell.2020.590195

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Tools for -mediated single copy insertion (mosSCI) with excisable or NeoR (G418) selection cassettes.

Aram R, MacGillivray K, Li C, Saltzman A
2019, microPublication biology, 2019, 32550440

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Multiple Histone Methyl-Lysine Readers Ensure Robust Development and Germline Immortality in Caenorhabditis elegans

Saltzman AL, Soo MW, Aram R, Lee JT
2018, Genetics, 10.1534/genetics.118.301518

Transgenerational Epigenetic Inheritance Is Negatively Regulated by the HERI-1 Chromodomain Protein

Perales R, Pagano D, Wan G, Fields BD, Saltzman AL, Kennedy SG
2018, Genetics, 10.1534/genetics.118.301456

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