Professor Arneet Saltzman

Arneet Saltzman

Assistant Professor


Campus

St. George (downtown)

CSB Appointment

Full

Research Areas

Animal Biology, Bioinformatics / Computational Biology, Cell Biology, Developmental Biology, Genetics / Genomics, Molecular Biology

Education

Research Fellow, Harvard Medical School, 2011-2017
Ph.D. University of Toronto, 2011
B.Sc. (Hons.) Queen’s University, 2003

Primary Undergraduate Department

Cell & Systems Biology

Graduate Programs

Cell & Systems Biology

Research Description

Most of the cells in an organism share the same genome sequence, yet they are able to carry out many distinct functions. Along with other layers of gene regulation, chromatin modification plays a key role in this cellular specialization. Our research focuses on histone modifications such as lysine methylation, and the proteins that recognize these modifications, which are often referred to as chromatin ‘readers’. Chromatin readers can recruit and act as part of diverse chromatin modifying protein complexes to mediate the silencing of many genes with important functions in cell proliferation and differentiation. We will use a combination of genetic, biochemical and genome-wide sequencing approaches to investigate the striking regulatory complexity of chromatin readers. Our research will contribute to a better understanding of how cells acquire and maintain different fates during development, how chromatin readers contribute to epigenetic inheritance, and how aberrant regulation of histone methylation contributes to the pathogenesis of several human diseases, including cancers.


Contact Information

Office Phone: 416-978-5328
Office: RW 514A
Lab: RW 509
Lab Phone: 416-978-4153
Email

Mailing Address

Department of Cell & Systems Biology
University of Toronto
25 Harbord St.
Toronto, ON M5S 3G5
Canada

Visit lab’s website


Publications

2020

Emerging Roles for Chromo Domain Proteins in Genome Organization and Cell Fate in C. elegans

DasGupta A, Lee TL, Li C, Saltzman AL
2020, Frontiers in Cell and Developmental Biology, 10.3389/fcell.2020.590195

Back to top

2019

Tools for -mediated single copy insertion (mosSCI) with excisable or NeoR (G418) selection cassettes.

Aram R, MacGillivray K, Li C, Saltzman A
2019, microPublication biology, 2019, 32550440

Back to top

2018

Multiple Histone Methyl-Lysine Readers Ensure Robust Development and Germline Immortality in Caenorhabditis elegans

Saltzman AL, Soo MW, Aram R, Lee JT
2018, Genetics, 10.1534/genetics.118.301518

Transgenerational Epigenetic Inheritance Is Negatively Regulated by the HERI-1 Chromodomain Protein

Perales R, Pagano D, Wan G, Fields BD, Saltzman AL, Kennedy SG
2018, Genetics, 10.1534/genetics.118.301456

Back to top