Professor Dorothea Godt

Dorothea Godt

Professor Emerita


St. George (downtown)

CSB Appointment

Emeritus, Full

Research Areas

Animal Biology, Cell Biology, Developmental Biology, Genetics / Genomics, Molecular Biology


Postdoctoral research 1991-1996, UCLA, USA
Ph.D. 1990, University of Cologne, Germany
Diploma 1985, Lud. Max. University Munich, Germany

Primary Undergraduate Department

Cell & Systems Biology

Graduate Programs

Cell & Systems Biology
Developmental Biology

Research Description

The behavior of individual cells is the driving force behind morphogenesis. Cell shape, cell motility, cell-cell and cell-matrix interactions, which can undergo rapid changes during development, determine the shape and organization of tissues and organs. To identify and analyze the molecular pathways and networks that regulate the behavior of cells during morphogenesis my research group uses gonad development in Drosophila as a model system. Our research focuses on (1) the formation of the germline stem cell niche, (2) invasive cell migration in ovarian follicles, and (3) development of microvilli in epithelial cells.

Contact Information

Office Phone: 416-978-8714
Office: RW608A
Lab: RW608/RW609
Lab Phone: 416-946-3691

Mailing Address

Department of Cell & Systems Biology
University of Toronto
25 Harbord St.
Toronto, ON M5S 3G5

Visit lab’s website

Recent News

Retirement celebration features fond recollections

CSB held an emotional get-together on Oct 18th in the Faculty Club to celebrate the retirements of Professors Dorotea Godt and Rudi Winklbauer, and…

Read More

CSB Researchers earn multiple NSERC awards

Congratulations to Professors in CSB who earned NSERC Discovery and NSERC-RTI grants! NSERC Discovery Grants The Discovery Grant program supports…

Read More



The NEMP family supports metazoan fertility and nuclear envelope stiffness

Tsatskis Y, Rosenfeld R, Pearson JD, Boswell C, Qu Y, Kim K, Fabian L, Mohammad A, Wang X, Robson MI, Krchma K, Wu J, Gonçalves J, Hodzic D, Wu S, Potter D, Pelletier L, Dunham WH, Gingras A, Sun Y, Meng J, Godt D, Schedl T, Ciruna B, Choi K, Perry JRB, Bremner R, Schirmer EC, Brill JA, Jurisicova A, McNeill H
2020, Science Advances, 10.1126/sciadv.abb4591

Integration of Migratory Cells into a New Site In Vivo Requires Channel-Independent Functions of Innexins on Microtubules

Miao G, Godt D, Montell DJ
2020, Developmental Cell, 10.1016/j.devcel.2020.06.024

Back to top


Dissection and Staining of Drosophila Pupal Ovaries

Park KS, Godt D, Kalderon D
2018, Journal of Visualized Experiments, 10.3791/56779

Back to top


Specification and spatial arrangement of cells in the germline stem cell niche of the Drosophila ovary depend on the Maf transcription factor Traffic jam

Xie T, Panchal T, Chen X, Alchits E, Oh Y, Poon J, Kouptsova J, Laski FA, Godt D
2017, PLOS Genetics, 10.1371/journal.pgen.1006790

Back to top


The E3 ligase Ubr3 regulates Usher syndrome and MYH9 disorder proteins in the auditory organs of Drosophila and mammals

Li T, Giagtzoglou N, Eberl DF, Jaiswal SN, Cai T, Godt D, Groves AK, Bellen HJ
2016, eLife, 10.7554/eLife.15258

Back to top


Loss of SPARC dysregulates basal lamina assembly to disrupt larval fat body homeostasis inDrosophila melanogaster

Shahab J, Baratta C, Scuric B, Godt D, Venken KJ, Ringuette MJ
2015, Developmental Dynamics, 10.1002/dvdy.24243

Back to top


Loss of SPARC dysregulates basal lamina assembly to disrupt larval fat body homeostasis in Drosophila melanogaster

Shahab J, Baratta C, Scuric B, Godt D, Venken KJ, Ringuette MJ
2014, Developmental dynamics : an official publication of the American Association of Anatomists, 25529377

Myosin VIIA regulates microvillus morphogenesis and interacts with cadherin Cad99C in Drosophila oogenesis

Glowinski C, Liu RH, Chen X, Darabie A, Godt D
2014, Journal of cell science, 127, 4821-32, 25236597

Back to top


The Maf factor Traffic jam both enables and inhibits collective cell migration in Drosophila oogenesis

Gunawan F, Arandjelovic M, Godt D
2013, Development (Cambridge, England), 140, 2808-17, 23720044

Back to top


Mutational analysis supports a core role for Drosophila α-catenin in adherens junction function

Sarpal R, Pellikka M, Patel RR, Hui FY, Godt D, Tepass U
2012, Journal of cell science, 125, 233-45, 22266901

Back to top


Breaking a temporal barrier: signalling crosstalk regulates the initiation of border cell migration

Godt D, Tepass U
2009, Nature cell biology, 11, 536-8, 19404334

The germline stem cells of Drosophila melanogaster partition DNA non-randomly

Karpowicz P, Pellikka M, Chea E, Godt D, Tepass U, van der Kooy D
2009, European journal of cell biology, 88, 397-408, 19395121

Cell dynamics and developmental bias in the ontogeny of a complex sexually dimorphic trait in Drosophila melanogaster

Atallah J, Liu NH, Dennis P, Hon A, Godt D, Larsen EW
2009, Evolution & development, 11, 191-204, 19245550

Back to top


Expression profile of the cadherin family in the developing Drosophila brain

Fung S, Wang F, Chase M, Godt D, Hartenstein V
2008, The Journal of comparative neurology, 506, 469-88, 18041774

Back to top


Integrin-dependent anchoring of a stem-cell niche

Tanentzapf G, Devenport D, Godt D, Brown NH
2007, Nature cell biology, 9, 1413-8, 17982446

Back to top


Drosophila melanogaster Cad99C, the orthologue of human Usher cadherin PCDH15, regulates the length of microvilli

D'Alterio C, Tran DD, Yeung MW, Hwang MS, Li MA, Arana CJ, Mulligan VK, Kubesh M, Sharma P, Chase M, Tepass U, Godt D
2005, The Journal of cell biology, 171, 549-58, 16260500

Talin’s second persona

Tepass U, Godt D
2005, Nature cell biology, 7, 443-4, 15867924

Back to top


The large Maf factor Traffic Jam controls gonad morphogenesis in Drosophila

Li MA, Alls JD, Avancini RM, Koo K, Godt D
2003, Nature cell biology, 5, 994-1000, 14578908

Hand-me-downs. Transmitting anterior-posterior asymmetry from older to younger egg follicles

Godt D, Tepass U
2003, Developmental cell, 5, 525-7, 14536049

The Drosophila melanogaster BTB proteins bric à brac bind DNA through a composite DNA binding domain containing a pipsqueak and an AT-Hook motif

Lours C, Bardot O, Godt D, Laski FA, Couderc JL
2003, Nucleic acids research, 31, 5389-98, 12954775

Organogenesis: keeping in touch with the germ cells

Godt D, Tepass U
2003, Current biology : CB, 13, R683-5, 12956974

Back to top


Cell sorting in animal development: signalling and adhesive mechanisms in the formation of tissue boundaries

Tepass U, Godt D, Winklbauer R
2002, Current opinion in genetics & development, 12, 572-82, 12200163

Back to top