Michael A. Phillips
Associate Professor
Campus
UTM
CSB Appointment
Full
Research Areas
Chemical Biology, Metabolomics, Molecular Biology, Plant Biology
Education
Ph.D. Washington State University 2000
BSc Humboldt State University (California) 1994
Primary Undergraduate Department
Biology, UTM
Graduate Programs
Cell & Systems Biology
Research Description
My research focuses on the regulation and control of plant terpenoid biosynthesis. We use mass spectrometry to study central terpenoid metabolism in Arabidopsis and specialized metabolism in glandular trichomes of medically important plant species.
Contact Information
Office Phone: 905-569-4848
Mailing Address
Department of Biology
University of Toronto
3359 Mississauga Road
Mississauga, ON L5L 1C6
Canada
Recent News
Publications
For the most current list of publications, visit my Google Scholar page: https://scholar.google.com/citations?user=bI4IfjcAAAAJ&hl=en
2024
Rubisco supplies pyruvate for the 2-C-methyl-d-erythritol-4-phosphate pathway
Evans SE, Xu Y, Bergman ME, Ford SA, Liu Y, Sharkey TD, Phillips MA
2024, Nature Plants, 10.1038/s41477-024-01791-z
A chromosome level reference genome of Diviner’s sage (Salvia divinorum) provides insight into salvinorin A biosynthesis
Ford SA, Ness RW, Kwon M, Ro D, Phillips MA
2024, BMC Plant Biology, 10.1186/s12870-024-05633-0
Plastid ancestors lacked a complete Entner-Doudoroff pathway, limiting plants to glycolysis and the pentose phosphate pathway
Evans SE, Franks AE, Bergman ME, Sethna NS, Currie MA, Phillips MA
2024, Nature Communications, 10.1038/s41467-024-45384-y
2023
Arabidopsis TGA256 Transcription Factors Suppress Salicylic-Acid-Induced Sucrose Starvation
Bergman ME, Evans SE, Kuai X, Franks AE, Despres C, Phillips MA
2023, Plants, 10.3390/plants12183284
2022
Biosynthesis, natural distribution, and biological activities of acyclic monoterpenes and their derivatives
Bergman ME, Franks AE, Phillips MA
2022, Phytochemistry Reviews, 10.1007/s11101-022-09849-6
An Arabidopsis GCMS chemical ionization technique to quantify adaptive responses in central metabolism
Bergman ME, Evans SE, Davis B, Hamid R, Bajwa I, Jayathilake A, Chahal AK, Phillips MA
2022, Plant Physiology, 10.1093/plphys/kiac207
Soapbark Triterpenes: Quillaja brasiliensis Cell Culture Sapogenin and Free Sterol Analysis by GCMS
Magedans YVS, Phillips MA
2022, , 10.1007/978-1-0716-2185-1_10
Design and fabrication of an improved dynamic flow cuvette for 13CO2 labeling in Arabidopsis plants
Evans SE, Duggan P, Bergman ME, Cobo-López D, Davis B, Bajwa I, Phillips MA
2022, Plant Methods, 10.1186/s13007-022-00873-3
2021
Production of plant bioactive triterpenoid saponins: from metabolites to genes and back
da Silva Magedans YV, Phillips MA, Fett-Neto AG
2021, Phytochemistry Reviews, 10.1007/s11101-020-09722-4
Structural diversity and biosynthesis of plant derived p-menthane monoterpenes
Bergman ME, Phillips MA
2021, Phytochemistry Reviews, 10.1007/s11101-020-09726-0
Isotope ratio-based quantification of carbon assimilation highlights the role of plastidial isoprenoid precursor availability in photosynthesis
Bergman ME, González-Cabanelas D, Wright LP, Walker BJ, Phillips MA
2021, Plant Methods, 10.1186/s13007-021-00731-8
Cytosolic geraniol and citronellol biosynthesis require a Nudix hydrolase in rose scented geranium (Pelargonium graveolens)
Bergman ME, Bhardwaj M, Phillips MA
2021, The Plant Journal, 10.1111/tpj.15304
Negative regulation of plastidial isoprenoid pathway by herbivore-induced β-cyclocitral in Arabidopsis thaliana
Mitra S, Estrada-Tejedor R, Volke DC, Phillips MA, Gershenzon J, Wright LP
2021, Proceedings of the National Academy of Sciences, 10.1073/pnas.2008747118
2020
Distinct metabolic pathways drive monoterpenoid biosynthesis in a natural population of Pelargonium graveolens.
Bergman ME, Chávez Á, Ferrer A, Phillips MA
2020, Journal of experimental botany, 71, 258-271, 31504760
Genetic dissection of climacteric fruit ripening in a melon population segregating for ripening behavior
Pereira L, Santo Domingo M, Ruggieri V, Argyris J, Phillips MA, Zhao G, Lian Q, Xu Y, He Y, Huang S, Pujol M, Garcia-Mas J
2020, Horticulture Research, 10.1038/s41438-020-00411-z
A Late Miocene to Late Pleistocene Reconstruction of Precipitation Isotopes and Climate From Hydrated Volcanic Glass Shards and Biomarkers in Central Alaska and Yukon
Otiniano GA, Porter TJ, Benowitz JA, Bindeman IN, Froese DG, Jensen BJL, Davies LJ, Phillips MA
2020, Paleoceanography and Paleoclimatology, 10.1029/2019PA003791
Cellular and Subcellular Compartmentation of the 2C-Methyl-D-Erythritol 4-Phosphate Pathway in the Madagascar Periwinkle
Guirimand G, Guihur A, Perello C, Phillips M, Mahroug S, Oudin A, Dugé de Bernonville T, Besseau S, Lanoue A, Giglioli-Guivarc’h N, Papon N, St-Pierre B, Rodríguez-Concepcíon M, Burlat V, Courdavault V
2020, Plants, 10.3390/plants9040462
2019
Medically Useful Plant Terpenoids: Biosynthesis, Occurrence, and Mechanism of Action.
Bergman ME, Davis B, Phillips MA
2019, Molecules (Basel, Switzerland), 24, 31683764
The plastidial metabolite 2-C-methyl-D-erythritol-2,4-cyclodiphosphate modulates defence responses against aphids
Onkokesung N, Reichelt M, Wright LP, Phillips MA, Gershenzon J, Dicke M
2019, Plant, Cell & Environment, 10.1111/pce.13538
2018
Nerolidol production in agroinfiltrated tobacco: Impact of protein stability and membrane targeting of strawberry (Fragraria ananassa) NEROLIDOL SYNTHASE1
Andrade P, Manzano D, Ramirez-Estrada K, Caudepon D, Arro M, Ferrer A, Phillips MA
2018, Plant Science, 10.1016/j.plantsci.2017.11.013
2017
Non-invasive quantification of ethylene in attached fruit headspace at 1 p.p.b. by gas chromatography-mass spectrometry
Pereira L, Pujol M, Garcia-Mas J, Phillips MA
2017, The Plant Journal, 10.1111/tpj.13545
2016
Differential Subplastidial Localization and Turnover of Enzymes Involved in Isoprenoid Biosynthesis in Chloroplasts.
Perello C, Llamas E, Burlat V, Ortiz-Alcaide M, Phillips MA, Pulido P, Rodriguez-Concepcion M
2016, PloS one, 11, e0150539, 26919668
Differential Subplastidial Localization and Turnover of Enzymes Involved in Isoprenoid Biosynthesis in Chloroplasts.
Perello C, Llamas E, Burlat V, Ortiz-Alcaide M, Phillips MA, Pulido P, Rodriguez-Concepcion M
2016, PloS one, 11, e0150539, 26919668
2015
Comparative transcriptional profiling analysis of developing melon (Cucumis melo L.) fruit from climacteric and non-climacteric varieties.
Saladié M, Cañizares J, Phillips MA, Rodriguez-Concepcion M, Larrigaudière C, Gibon Y, Stitt M, Lunn JE, Garcia-Mas J
2015, BMC genomics, 16, 440, 26054931
The diversion of 2-C-methyl-D-erythritol-2,4-cyclodiphosphate from the 2-C-methyl-D-erythritol 4-phosphate pathway to hemiterpene glycosides mediates stress responses in Arabidopsis thaliana.
González-Cabanelas D, Wright LP, Paetz C, Onkokesung N, Gershenzon J, Rodríguez-Concepción M, Phillips MA
2015, The Plant journal : for cell and molecular biology, 82, 122-37, 25704332
2014
The 2-C-methylerythritol 4-phosphate pathway in melon is regulated by specialized isoforms for the first and last steps.
Saladié M, Wright LP, Garcia-Mas J, Rodriguez-Concepcion M, Phillips MA
2014, Journal of experimental botany, 65, 5077-92, 25013119
Deoxyxylulose 5-Phosphate Synthase Controls Flux through the Methylerythritol 4-Phosphate Pathway in Arabidopsis.
Wright LP, Rohwer JM, Ghirardo A, Hammerbacher A, Ortiz-Alcaide M, Raguschke B, Schnitzler JP, Gershenzon J, Phillips MA
2014, Plant physiology, 165, 1488-1504, 24987018
Measuring the activity of 1-deoxy-D-xylulose 5-phosphate synthase, the first enzyme in the MEP pathway, in plant extracts.
Wright LP, Phillips MA
2014, Methods in molecular biology (Clifton, N.J.), 1153, 9-20, 24777787
Influence of medium and elicitors on the production of cocaine, amino acids and phytohormones by Erythroxylum coca calli
Docimo T, Davis AJ, Luck K, Fellenberg C, Reichelt M, Phillips M, Gershenzon J, D’Auria JC
2014, Plant Cell, Tissue and Organ Culture (PCTOC), 10.1007/s11240-014-0660-8
2013
Arabidopsis J-protein J20 delivers the first enzyme of the plastidial isoprenoid pathway to protein quality control.
Pulido P, Toledo-Ortiz G, Phillips MA, Wright LP, Rodríguez-Concepción M
2013, The Plant cell, 25, 4183-94, 24104567
Arabidopsis J-protein J20 delivers the first enzyme of the plastidial isoprenoid pathway to protein quality control.
Pulido P, Toledo-Ortiz G, Phillips MA, Wright LP, Rodríguez-Concepción M
2013, The Plant cell, 25, 4183-94, 24104567
2012
Triple subcellular targeting of isopentenyl diphosphate isomerases encoded by a single gene.
Guirimand G, Guihur A, Phillips MA, Oudin A, Glévarec G, Mahroug S, Melin C, Papon N, Clastre M, Giglioli-Guivarc\'h N, St-Pierre B, Rodríguez-Concepción M, Burlat V, Courdavault V
2012, Plant signaling & behavior, 7, 1495-7, 22951398
A single gene encodes isopentenyl diphosphate isomerase isoforms targeted to plastids, mitochondria and peroxisomes in Catharanthus roseus.
Guirimand G, Guihur A, Phillips MA, Oudin A, Glévarec G, Melin C, Papon N, Clastre M, St-Pierre B, Rodríguez-Concepción M, Burlat V, Courdavault V
2012, Plant molecular biology, 79, 443-59, 22638903
2009
Pleiotropic regulatory locus 1 (PRL1) integrates the regulation of sugar responses with isoprenoid metabolism in Arabidopsis.
Flores-Pérez U, Pérez-Gil J, Closa M, Wright LP, Botella-Pavía P, Phillips MA, Ferrer A, Gershenzon J, Rodríguez-Concepción M
2010, Molecular plant, 3, 101-12, 20008452
Evaluation of Candidate Reference Genes for Real-Time Quantitative PCR of Plant Samples Using Purified cDNA as Template.
Phillips MA, D\'Auria JC, Luck K, Gershenzon J
2009, Plant molecular biology reporter, 27, 407-416, 24489433
Quantitative iTRAQ proteome and comparative transcriptome analysis of elicitor-induced Norway spruce (Picea abies) cells reveals elements of calcium signaling in the early conifer defense response.
Lippert DN, Ralph SG, Phillips M, White R, Smith D, Hardie D, Gershenzon J, Ritland K, Borchers CH, Bohlmann J
2009, Proteomics, 9, 350-67, 19105170
2008
The plastidial MEP pathway: unified nomenclature and resources.
Phillips MA, León P, Boronat A, Rodríguez-Concepción M
2008, Trends in plant science, 13, 619-23, 18948055
The Arabidopsis thaliana type I Isopentenyl Diphosphate Isomerases are targeted to multiple subcellular compartments and have overlapping functions in isoprenoid biosynthesis.
Phillips MA, D\'Auria JC, Gershenzon J, Pichersky E
2008, The Plant cell, 20, 677-96, 18319397
2007
Functional identification and differential expression of 1-deoxy-D-xylulose 5-phosphate synthase in induced terpenoid resin formation of Norway spruce (Picea abies).
Phillips MA, Walter MH, Ralph SG, Dabrowska P, Luck K, Urós EM, Boland W, Strack D, Rodríguez-Concepción M, Bohlmann J, Gershenzon J
2007, Plant molecular biology, 65, 243-57, 17687625
Functional identification and differential expression of 1-deoxy-D-xylulose 5-phosphate synthase in induced terpenoid resin formation of Norway spruce (Picea abies).
Phillips MA, Walter MH, Ralph SG, Dabrowska P, Luck K, Urós EM, Boland W, Strack D, Rodríguez-Concepción M, Bohlmann J, Gershenzon J
2007, Plant molecular biology, 65, 243-57, 17687625
2006
Molecular Regulation of Induced Terpenoid Biosynthesis in Conifers
Phillips MA, Bohlmann J, Gershenzon J
2006, Phytochemistry Reviews, 10.1007/s11101-006-0001-6
2004
Metabolic engineering of isoprenoid biosynthesis in Arabidopsis for the production of taxadiene, the first committed precursor of Taxol.
Besumbes O, Sauret-Güeto S, Phillips MA, Imperial S, Rodríguez-Concepción M, Boronat A
2004, Biotechnology and bioengineering, 88, 168-75, 15449291
Regulation of carotenoid biosynthesis in plants: evidence for a key role of hydroxymethylbutenyl diphosphate reductase in controlling the supply of plastidial isoprenoid precursors.
Botella-Pavía P, Besumbes O, Phillips MA, Carretero-Paulet L, Boronat A, Rodríguez-Concepción M
2004, The Plant journal : for cell and molecular biology, 40, 188-99, 15447646
2003
Distinct light-mediated pathways regulate the biosynthesis and exchange of isoprenoid precursors during Arabidopsis seedling development.
Rodríguez-Concepción M, Forés O, Martinez-García JF, González V, Phillips MA, Ferrer A, Boronat A
2004, The Plant cell, 16, 144-56, 14660801
cDNA isolation, functional expression, and characterization of (+)-alpha-pinene synthase and (-)-alpha-pinene synthase from loblolly pine (Pinus taeda): stereocontrol in pinene biosynthesis.
Phillips MA, Wildung MR, Williams DC, Hyatt DC, Croteau R
2003, Archives of biochemistry and biophysics, 411, 267-76, 12623076
1999
Monoterpene synthases of loblolly pine (Pinus taeda) produce pinene isomers and enantiomers.
Phillips MA, Savage TJ, Croteau R
1999, Archives of biochemistry and biophysics, 372, 197-204, 10562434