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| Mailing Address |
| Department of Cell & Systems Biology University of Toronto 25 Harbord St. Toronto, ON M5S 3G5 Canada |
| Contact Information |
| Office phone: 416-946-0338 Office: RW 619A Lab: RW 607 / 619 Lab phone: 416-946-0593/7218 Email: v.tropepe@utoronto.ca URL: http://sites.utoronto.ca/tropepe-lab/Welcome.html |
| Research Areas |
| Cell Biology Developmental Biology Functional Genomics Genetics Molecular Biology Neurobiology |
| Research |
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The production of nerve cells (neurogenesis) is a life-long process with regional specialization that is critical for the formation of distinct functional domains in the vertebrate nervous system. Moreover, neurogenesis in the mature nervous system may contribute to the structural changes that underlie neural plasticity, which is crucial for sensory processing and behaviour. My lab investigates how neurogenesis contributes to the generation and maintenance of regional nerve cell diversity throughout life. We utilize various molecular genetic techniques in order to identify and characterize the molecular mechanisms that govern vertebrate neurogenesis. |
| Publications |
2018Top |
| Neural stem cell heterogeneity..Joly JS, Tropepe V. Prog. Neurobiol. 2018 11; 170():1 pubmed |
| The role of neuro-epithelial-like and radial-glial stem and progenitor cells in development, plasticity, and repair..Lindsey BW, Hall ZJ, Heuzé A, Joly JS, Tropepe V, Kaslin J. Prog. Neurobiol. 2018 11; 170():99-114 pubmed |
| Movement maintains forebrain neurogenesis via peripheral neural feedback in larval zebrafish..Hall ZJ, Tropepe V. Elife 2018 03 12; 7(): pubmed |
2017Top |
| Cone-like rhodopsin expressed in the all-cone retina of the colubrid pine snake as a potential adaptation to diurnality..Bhattacharyya N, Darren B, Schott RK, Tropepe V, Chang BSW. J. Exp. Biol. 2017 07 01; 220(Pt 13):2418-2425 pubmed |
| A second visual rhodopsin gene, rh1-2, is expressed in zebrafish photoreceptors and found in other ray-finned fishes..Morrow JM, Lazic S, Dixon Fox M, Kuo C, Schott RK, de A Gutierrez E, Santini F, Tropepe V, Chang BS. J. Exp. Biol. 2017 01 15; 220(Pt 2):294-303 pubmed |
2016Top |
| G9a and ZNF644 Physically Associate to Suppress Progenitor Gene Expression during Neurogenesis..Olsen JB, Wong L, Deimling S, Miles A, Guo H, Li Y, Zhang Z, Greenblatt JF, Emili A, Tropepe V. Stem Cell Reports 2016 09 13; 7(3):454-470 pubmed |
| Evolutionary transformation of rod photoreceptors in the all-cone retina of a diurnal garter snake..Schott RK, Müller J, Yang CG, Bhattacharyya N, Chan N, Xu M, Morrow JM, Ghenu AH, Loew ER, Tropepe V, Chang BS. Proc. Natl. Acad. Sci. U.S.A. 2016 Jan 12; 113(2):356-61 pubmed |
2015Top |
| Nonsense mutation in the WDR73 gene is associated with Galloway-Mowat syndrome..Ben-Omran T, Fahiminiya S, Sorfazlian N, Almuriekhi M, Nawaz Z, Nadaf J, Khadija KA, Zaineddin S, Kamel H, Majewski J, Tropepe V. J. Med. Genet. 2015 Jun; 52(6):381-90 pubmed |
| Mutual antagonism of the paired-type homeobox genes, vsx2 and dmbx1, regulates retinal progenitor cell cycle exit upstream of ccnd1 expression..Wong L, Power N, Miles A, Tropepe V. Dev. Biol. 2015 Jun 15; 402(2):216-28 pubmed |
2014Top |
| Changes in the social environment induce neurogenic plasticity predominantly in niches residing in sensory structures of the zebrafish brain independently of cortisol levels.Lindsey BW, Tropepe V. Dev Neurobiol 2014 Apr; pubmed |
| Casting a wider fish net on animal models in neuropsychiatric research.Hall ZJ, De Serrano AR, Rodd FH, Tropepe V. Prog. Neuropsychopharmacol. Biol. Psychiatry 2014 Apr; pubmed |
2013Top |
| Cockayne syndrome b maintains neural precursor function.Sacco R, Tamblyn L, Rajakulendran N, Bralha FN, Tropepe V, Laposa RR. DNA Repair (Amst.) 2013 Feb;12(2):110-20 pubmed |
2012Top |
| Toll-like signaling and the cytokine IL-6 regulate histone deacetylase dependent neuronal survival.Forgione N, Tropepe V. PLoS ONE 2012;7(7):e41033 pubmed |
| Zfhx1b induces a definitive neural stem cell fate in mouse embryonic stem cells.Dang LT, Wong L, Tropepe V. Stem Cells Dev. 2012 Oct;21(15):2838-51 pubmed |
| The ontogeny of somatic stem cells.Tropepe V, Turksen K. Stem Cell Rev 2012 Jun;8(2):548-50 pubmed |
| The cellular composition of neurogenic periventricular zones in the adult zebrafish forebrain.Lindsey BW, Darabie A, Tropepe V. J. Comp. Neurol. 2012 Jul;520(10):2275-316 pubmed |
2011Top |
| Histone deacetylase inhibition promotes Caspase-independent cell death of ventral midbrain neurons.Forgione N, Tropepe V. Mol. Cell. Neurosci. 2011 Oct;48(2):117-28 pubmed |
| The role of dopaminergic signalling during larval zebrafish brain development: a tool for investigating the developmental basis of neuropsychiatric disorders.Souza BR, Tropepe V. Rev Neurosci 2011;22(1):107-19 pubmed |
| Dopamine D2 receptor activity modulates Akt signaling and alters GABAergic neuron development and motor behavior in zebrafish larvae.Souza BR, Romano-Silva MA, Tropepe V. J. Neurosci. 2011 Apr;31(14):5512-25 pubmed |
| The PI3K/Akt/mTOR pathway mediates retinal progenitor cell survival under hypoxic and superoxide stress.Sanghera KP, Mathalone N, Baigi R, Panov E, Wang D, Zhao X, Hsu H, Wang H, Tropepe V, Ward M, Boyd SR. Mol. Cell. Neurosci. 2011 Jun;47(2):145-53 pubmed |
2010Top |
| Waste management and adult neurogenesis.Mattocks M, Tropepe V. Cell Stem Cell 2010 Oct;7(4):421-2 pubmed |
| Duplicate dmbx1 genes regulate progenitor cell cycle and differentiation during zebrafish midbrain and retinal development.Wong L, Weadick CJ, Kuo C, Chang BS, Tropepe V. BMC Dev. Biol. 2010;10:100 pubmed |
| FGF dependent regulation of Zfhx1b gene expression promotes the formation of definitive neural stem cells in the mouse anterior neurectoderm.Dang LT, Tropepe V. Neural Dev 2010;5:13 pubmed |
2009Top |
| Neurogenic potential of isolated precursor cells from early post-gastrula somitic tissue.Tropepe V, Alton K, Sachewsky N, Cheng V, Kuo C, Morshead CM. Stem Cells Dev. 2009 Dec;18(10):1533-42 pubmed |
2007Top |
| Kinship and descent: redefining the stem cell compartment in the adult hippocampus.Tropepe V. Cell Stem Cell 2007 Nov;1(5):481-3 pubmed |
| Kinship and Descent: Redefining the Stem Cell Compartment in the Adult Hippocampus.Tropepe V. Cell Stem Cell 2007 Nov;1(5):481-483 pubmed |
2006Top |
| Neural induction and neural stem cell development.Dang L, Tropepe V. Regen Med 2006 Sep;1(5):635-52 pubmed |
| A comparative framework for understanding the biological principles of adult neurogenesis.Lindsey BW, Tropepe V. Prog. Neurobiol. 2006 Dec;80(6):281-307 pubmed |
| Genomic sequence and spatiotemporal expression comparison of zebrafish mbx1 and its paralog, mbx2.Chang L, Khoo B, Wong L, Tropepe V. Dev. Genes Evol. 2006 Oct;216(10):647-54 pubmed |
| Identification of a BMP inhibitor-responsive promoter module required for expression of the early neural gene zic1.Tropepe V, Li S, Dickinson A, Gamse JT, Sive HL. Dev. Biol. 2006 Jan;289(2):517-29 pubmed |
2002Top |
| Notch pathway molecules are essential for the maintenance, but not the generation, of mammalian neural stem cells.Hitoshi S, Alexson T, Tropepe V, Donoviel D, Elia AJ, Nye JS, Conlon RA, Mak TW, Bernstein A, van der Kooy D. Genes Dev. 2002 Apr;16(7):846-58 pubmed |
| Neural stem cell lineages are regionally specified, but not committed, within distinct compartments of the developing brain.Hitoshi S, Tropepe V, Ekker M, van der Kooy D. Development 2002 Jan;129(1):233-44 pubmed |